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Cleavage of Qinghaosu (Artemisinin) Induced by Non‐Iron Transition‐Metal Ions in the Presence of Excess Cysteine
Author(s) -
Wu Yikang,
Liu HeHua
Publication year - 2003
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200390249
Subject(s) - chemistry , cleavage (geology) , transition metal , cysteine , catalysis , artemisinin , ion , metal , inorganic chemistry , organic chemistry , geotechnical engineering , immunology , fracture (geology) , malaria , engineering , plasmodium falciparum , biology , enzyme
In the presence of an excess of cysteine, a catalytic amount of a non‐iron transition‐metal ion (Co 2+ , Cu 2+ , Ni 2+ , Ti 4+ , and Mn 2+ ) may also induce cleavage of qinghaosu (artemisinin; 1 ) to give those end products previously reported for Fe 2+ ‐mediated degradation.
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