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Indoloquinazoline Alkaloids from Araliopsis tabouensis
Author(s) -
Christopher Ezugwu,
Bedir Erdal,
Dunbar Chuck,
Khan Ikhlas A.,
Okunji Christopher O.,
Schuster Brian M.,
Iwu Maurice M.
Publication year - 2003
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200390239
Subject(s) - chemistry , plasmodium falciparum , stereochemistry , bioassay , alkaloid , chloride , organic chemistry , malaria , genetics , immunology , biology
Three new indoloquinazolidine‐type alkaloids, 8,13‐dihydro‐2‐methoxyindolo[2′,3′: 3,4]pyrido[2,1‐ b ]quinazolin‐5(7 H )‐one ( 1 ), 8,13‐dihydro‐2‐methoxy‐13‐methylindolo[2′,3′: 3,4]pyrido[2,1‐ b ]quinazolin‐5(7 H )‐one ( 2 ), and 5,8,13,14‐tetrahydro‐2‐methoxy‐14‐methyl‐5‐oxo‐7 H ‐indolo[2′,3′: 3,4]pyrido[2,1‐ b ]quinazolim‐6‐iun chloride ( 3 ) were isolated from Araliopsis tabouensis , together with three known compounds. The structures of the new compounds were determined primarily from 1D‐ and 2D‐NMR analysis. The antimalarial activities of compounds 1 – 5 were evaluated against Plasmodium falciparum D6 and W2 clones. The IC 50 values in antimalarial bioassay for compounds 2 – 5 varied from 1.8 to 4.7 μg/ml.