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A Diterpenoid with a New Skeleton and Cytotoxic Terpenoids Isolated from Amentotaxus formosana
Author(s) -
Su HueyJen,
Wang LiWen,
Lin ChunNan,
Day ShiowHwa,
Wei BaiLuh,
Yang ShengZehn,
Won ShenJeu
Publication year - 2003
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200390214
Subject(s) - terpenoid , chemistry , stereochemistry , bark (sound) , cytotoxic t cell , skeleton (computer programming) , in vitro , biochemistry , biology , ecology , anatomy
The new diterpenoid 6 α ‐hydroxy‐ ent ‐kaur‐16‐en‐15‐one ( 1 ) and a diterpenoid with a new skeleton, i.e. , amentotaxin BB ( 5 ), as well as three new lanostanoids, i.e. , (3 β ,23 R )‐3‐methoxy‐24‐methylenelanost‐8‐en‐23‐ol ( 6 ), (23 S )‐23‐methoxy‐24‐methylenelanost‐8‐en‐3‐one ( 7 ), and (3 β ,24 ξ )‐3‐methoxy‐24‐methyl‐9,19‐cyclolanostan‐25‐ol ( 8 ), were isolated from the bark and leaves of Amentotaxus formosana. Their structures, including the relative configurations, were elucidated from spectroscopic data. Compound 1 and a known compound, ent ‐kaur‐16‐en‐15‐one ( 2 ), showed potent cytotoxic effects against a number of cancer cells in vitro.
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