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Novel Anti‐Inflammatory Constituents of Artocarpus rigida
Author(s) -
Lu YiHuang,
Lin ChunNan,
Ko HorngHuey,
Yang ShengZehn,
Tsao LoTi,
Wang JihPyang
Publication year - 2003
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200390207
Subject(s) - chemistry , superoxide , moraceae , bark (sound) , cytochalasin , artocarpus , stereochemistry , organic chemistry , biochemistry , traditional medicine , botany , enzyme , physics , cytoskeleton , acoustics , cell , medicine , biology
A novel phenolic compound containing an oxepine ring, artocarpol I ( 1 ), and a new biphenylpropanoid, artocarpol J ( 2 ), were isolated from the root bark of Artocarpus rigida. The structures, including relative configurations, were elucidated by spectroscopic data. Compound 1 and artocarpol J peracetate ( 3 ) strongly inhibited in a concentration‐dependent manner the formyl‐Met‐Leu‐Phe (fMLP)/cytochalasin B (CB)‐stimulated superoxide anion formation in neutrophils with IC 50 values of 17.1±0.40 and 20.5±2.60 μ M , respectively. Biogenetically, all the novel phenolic compounds isolated from this plant seem to be derived from stilbene.