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Cytotoxic Constituents of Piper sintenense
Author(s) -
Chen JihJung,
Duh ChangYih,
Huang HungYi,
Chen IhSheng
Publication year - 2003
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200390161
Subject(s) - chemistry , stereochemistry , piper , sesamin , furan , lignan , alkaloid , organic chemistry , traditional medicine , food science , medicine
Abstract A new pyridone alkaloid, 5,6‐dihydro‐5‐hydroxy‐1 H ‐pyridin‐2‐one ( 1 ), and a new ester, sintenin (=3‐(3,4‐dimethoxyphenyl)propyl 3‐(3,4‐dimethoxyphenyl)propanoate 2 ), together with three known compounds, 5,6‐dihydro‐1 H ‐pyridin‐2‐one ( 3 ), d ‐sesamin (=5,5′‐(3a,4,6,6a‐tetrahydro‐1 H ,3 H ‐furo[3,4‐ c ]furan‐1,4‐diyl)bis[1,3‐benzodioxole]; 4 ), and ( E )‐phytol (=3,7,11,15‐tetramethylhexadec‐2‐en‐1‐ol; 5 ) have been isolated from the whole plant of Piper sintenense. The structures of the two new compounds were determined through spectral analyses. Among twenty isolates obtained so far, four compounds exhibited effective cytotoxicities against P‐388, HT‐29, or A549 cell lines in vitro.