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Pentopyranosyl Oligonucleotide Systems. Communication No. 13
Author(s) -
Jungmann Oliver,
Beier Markus,
Luther Anatol,
Huynh Hoan K.,
Ebert MarcOlivier,
Jaun Bernhard,
Krishnamurthy Ramanarayanan,
Eschenmoser Albert
Publication year - 2003
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200390118
Subject(s) - oligonucleotide , chemistry , pairing , base pair , dna , rna , base (topology) , stereochemistry , biochemistry , gene , physics , superconductivity , quantum mechanics , mathematical analysis , mathematics
Among the members of a family of diastereoisomeric pentopyranosyl‐(4′→2′)‐oligonucleotide systems derived from D ‐ribose, D ‐xylose, L ‐lyxose, and L ‐arabinose, the α ‐arabinopyranosyl system shows by far the strongest Watson Crick base pairing. The system is, in fact, one of the strongest oligonucleotide‐type base‐pairing systems known. It undergoes efficient cross‐pairing with all the other members of the pentopyranosyl family, but not with RNA and DNA. The paper describes the synthesis and pairing of the properties of α ‐ L ‐arabinopyranosyl‐(4′→2′)‐oligonucleotides.