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Synthesis of a Tridentate Ligand for Use in Ti IV ‐Catalyzed Acetate Aldol Addition Reactions
Author(s) -
Singer Robert A.,
Brock Jane R.,
Carreira Erick M.
Publication year - 2003
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200390092
Subject(s) - chemistry , salicylaldehyde , aldol reaction , ligand (biochemistry) , enantioselective synthesis , catalysis , schiff base , aldol condensation , condensation reaction , organic chemistry , addition reaction , medicinal chemistry , polymer chemistry , combinatorial chemistry , receptor , biochemistry
A facile, practical synthesis and resolution of (±)‐2′‐amino‐[1,1′‐binaphthalen]‐2‐ol ( 1 ) is described, as well as the preparation of the tridentate Schiff base ligand 2 derived from condensation of 1 with 3‐bromo‐5‐( tert ‐butyl)salicylaldehyde, which has been used in catalytic enantioselective acetate aldol addition reactions.