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A New Synthesis of Optically Active 3‐Substituted (3 S )‐3,4‐Dihydro‐5‐(perfluoroalkyl)‐2 H ‐[1,4]oxazepin‐7‐ones
Author(s) -
Richard Sébastien,
Prié Gildas,
Guignard Alain,
Thibonnet Jérôme,
Parrain J.Luc,
Duchêne Alain,
Abarbri Mohamed
Publication year - 2003
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200390071
Subject(s) - chemistry , optically active , intermolecular force , combinatorial chemistry , stereochemistry , organic chemistry , molecule
Optically active (perfluoroalkyl)‐oxazepin‐7‐ones were synthesized in two steps starting from ethyl perfluorobut‐2‐ynoate by direct addition of optically active amino alcohols via intermolecular Michael addition and lactone formation.