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Leptosphaeric Acid, a Metabolite with a Novel Carbon Skeleton from Leptosphaeria sp. IV403, an Endophytic Fungus in Artemisia annua
Author(s) -
Liu JunYan,
Liu ChangHong,
Zou WenXin,
Tan RenXiang
Publication year - 2003
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200390064
Subject(s) - chemistry , metabolite , carbon skeleton , artemisia annua , stereochemistry , artemisia , fungus , absolute configuration , two dimensional nuclear magnetic resonance spectroscopy , heteronuclear molecule , secondary metabolite , botany , nuclear magnetic resonance spectroscopy , biochemistry , biology , plasmodium falciparum , artemisinin , malaria , gene , immunology
Leptosphaeric acid ( 1 ), a metabolite with a novel carbon skeleton, was isolated from the AcOEt extract of the culture of Leptosphaeria sp., an endophytic fungus (strain number: IV403) of Artemisia annua. The structure of acid 1 was elucidated on the basis of spectral analyses including homo‐ and heteronuclear correlation NMR experiments (HMQC and HMBC). The absolute configuration of the metabolite was determined by its CD and NOED studies.