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Three Tyrosinase Inhibitors and Antioxidant Compounds from Salsola foetida
Author(s) -
Khan Khalid Mohammed,
Maharvi Ghulam Murtaza,
Abbaskhan Ahmed,
Hayat Safdar,
Khan Mahmud Tareq Hassan,
Makhmoor Talat,
Choudhary M. Iqbal,
Shaheen Farzana
Publication year - 2003
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200390045
Subject(s) - chemistry , tyrosinase , dpph , antioxidant , phytochemical , stereochemistry , traditional medicine , organic chemistry , biochemistry , enzyme , medicine
Phytochemical investigation on the whole plant of Salsola foetida resulted in the isolation of three new phenolic compounds 1, 2 , and 3 , which exhibit tyrosinase inhibition with moderate antioxidant activity. Compounds 1 – 3 inhibited tyrosinase with IC 50 2.61, 1.85, and 0.40 μ M , while exhibiting DPPH radical scavenging activity with IC 50 383, 427 and 378 μ M , respectively. The structures of 1, 2 , and 3 were determined by modern spectroscopic techniques.