Cyclic RGD Peptides Containing Azabicycloalkane Reverse‐Turn Mimics | Zendy

Belvisi Laura | Zendy; Caporale Andrea | Zendy; Colombo Matteo | Zendy; Manzoni Leonardo | Zendy; Potenza Donatella | Zendy; Scolastico Carlo | Zendy; Castorina Massimo | Zendy; Cati Matilde | Zendy; Giannini Giuseppe | Zendy; Pisano Claudio | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Cyclic RGD Peptides Containing Azabicycloalkane Reverse‐Turn Mimics

Author(s) -

Belvisi Laura,

Caporale Andrea,

Colombo Matteo,

Manzoni Leonardo,

Potenza Donatella,

Scolastico Carlo,

Castorina Massimo,

Cati Matilde,

Giannini Giuseppe,

Pisano Claudio

Publication year - 2002

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200290017

Subject(s) - chemistry , integrin , lactam , stereochemistry , cyclic peptide , turn (biochemistry) , peptide , combinatorial chemistry , biochemistry , receptor

The Fmoc‐protected lactams 3 and 4 were used to prepare cyclo(Arg‐Gly‐Asp‐lactam) 1 and cyclo(Arg‐Gly‐Asp‐Phe‐lactam) 2 , which contain the Arg‐Gly‐Asp (RGD) recognition motif. Their solid‐phase synthesis, conformational analysis, and binding to purified α V β 3 and α V β 5 integrins are reported. Compound 1 was found to act as an active and selective inhibitor of the α V β 5 integrin.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research