Enantioselektive Synthese von α‐substituierten N ‐Methyl‐sulfonamiden. Vorläufige Mitteilung

The first asymmetric α‐alkylations of lithiated sulfonamides bearing the chirality information within the amine moiety under high asymmetric inductions (de 83–95%) are described. Racemization‐free acidic hydrolysis led to the title compounds 11 in acceptable overall yields and with high enantiomeric purity (ee 91− ≥ 98%; Scheme 2 ). As a novel chiral auxiliary, the primary amine ( S , S )‐or ( R , R )‐ 2 was synthesized employing the classical Erlenmeyer phenylserine synthesis ( Scheme 1 ).