Synthesis and Biological Evaluation of 14‐Alkoxymorphinans. Part 15.  Novel δ opiod receptor antagonists with high affinity and selectivity in the 14‐alkoxy‐substituted indolomorphinan series | Zendy

Schmidhammer Helmut | Zendy; Krassnig Roland | Zendy; Greiner Elisabeth | Zendy; Schütz Johannes | Zendy; White Angela | Zendy; BerzeteiGurske Ilona P. | Zendy

Premium

Synthesis and Biological Evaluation of 14‐Alkoxymorphinans. Part 15. Novel δ opiod receptor antagonists with high affinity and selectivity in the 14‐alkoxy‐substituted indolomorphinan series

Author(s) -

Schmidhammer Helmut,

Krassnig Roland,

Greiner Elisabeth,

Schütz Johannes,

White Angela,

BerzeteiGurske Ilona P.

Publication year - 1998

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19980810519

Subject(s) - chemistry , vas deferens , alkoxy group , potency , antagonist , selectivity , stereochemistry , receptor , indole test , opioid , pharmacology , combinatorial chemistry , in vitro , biochemistry , organic chemistry , alkyl , medicine , catalysis

The indolomorphinans 4 – 7 were prepared from their corresponding morphinan‐6‐one derivatives 8 – 11 via Fischer indole synthesis. Compounds 4 and 5 exhibited higher antagonist potency at δ opioid receptors in the mouse vas deferens preparation than the reference drug HS 378 ( 2 ), while compounds 6 and 7 were less potent.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research