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Kinetic Study of the Reaction of Pyridoxal 5′‐Phosphate with Hydrazino Compounds of Pharmacological Activity
Author(s) -
EchevarríaGorostidi Gerardo R.,
Basagoitia Andrea,
Pizarro Eliana,
Goldsmid Ruth,
Blanco José G. Santos,
Blanco Francisco García
Publication year - 1998
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19980810505
Subject(s) - chemistry , hydrazine (antidepressant) , ionic strength , reaction rate constant , aqueous solution , hydrolysis , pyridoxal , reactivity (psychology) , pyridoxal 5 phosphate , schiff base , isoniazid , inorganic chemistry , kinetics , medicinal chemistry , phosphate , organic chemistry , polymer chemistry , chromatography , medicine , tuberculosis , physics , alternative medicine , quantum mechanics , pathology
The kinetics of the reaction between pyridoxal 5′‐phosphate (PLP) with carbidopa, hydralazine, and isoniazid, in aqueous solution at variable pH and constant ionic strength of 0.1 M was studied spectrophotometrically. The rate constants of formation and hydrolysis of the resulting Schiff base, and its stability were determined in a wide range of pH. A comparison is made of the formation rate constants with those of PLP with hydrazine. The reactivity shows the sequence isoniazid > hydrazine > carbidopa > hydralazine in the whole range of pH studied. The Schiff bases studied are more stable than those formed by PLP and hexylamine and as stable as those described for the reactions of PLP with poly( L ‐lysine) or copolypeptides containing L ‐lysine.