Synthesis and transformations of methyl ( E )‐2‐(acetylamino)‐3‐cyanoprop‐2‐enoate und methyl ( E )‐2‐(benzoylamino)‐3‐cyanoprop‐2‐enoate, versatile reagents for the preparation of polyfunctional heterocyclic systems | Zendy

Pizzioli Lucija | Zendy; Ornik Brina | Zendy; Svete Jurij | Zendy; Stanovnik Branko | Zendy

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Synthesis and transformations of methyl ( E )‐2‐(acetylamino)‐3‐cyanoprop‐2‐enoate und methyl ( E )‐2‐(benzoylamino)‐3‐cyanoprop‐2‐enoate, versatile reagents for the preparation of polyfunctional heterocyclic systems

Author(s) -

Pizzioli Lucija,

Ornik Brina,

Svete Jurij,

Stanovnik Branko

Publication year - 1998

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19980810205

Subject(s) - chemistry , synthon , reagent , medicinal chemistry , stereochemistry , organic chemistry , combinatorial chemistry

Methyl ( E )‐2‐(acetylamino)‐3‐cyanoprop‐2‐enoate ( 2a ), and its 2‐benzoyl analog 2b ere prepared from the corresponding methyl ( Z )‐2‐(acylamino)‐3‐(dimethylamino)propenoates 1 Multifunctional compounds 2 are versatile synthons for preparation of polysubstituted heterocyclic systems such as pyrroles 4 , pyrimidines 5 and 6 , pyridazines 7 , pyrazoles 8 , 9 , and 11 , and isoxazoles 10 .

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