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Synthesis and transformations of methyl ( E )‐2‐(acetylamino)‐3‐cyanoprop‐2‐enoate und methyl ( E )‐2‐(benzoylamino)‐3‐cyanoprop‐2‐enoate, versatile reagents for the preparation of polyfunctional heterocyclic systems
Author(s) -
Pizzioli Lucija,
Ornik Brina,
Svete Jurij,
Stanovnik Branko
Publication year - 1998
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19980810205
Subject(s) - chemistry , synthon , reagent , medicinal chemistry , stereochemistry , organic chemistry , combinatorial chemistry
Methyl ( E )‐2‐(acetylamino)‐3‐cyanoprop‐2‐enoate ( 2a ), and its 2‐benzoyl analog 2b ere prepared from the corresponding methyl ( Z )‐2‐(acylamino)‐3‐(dimethylamino)propenoates 1 Multifunctional compounds 2 are versatile synthons for preparation of polysubstituted heterocyclic systems such as pyrroles 4 , pyrimidines 5 and 6 , pyridazines 7 , pyrazoles 8 , 9 , and 11 , and isoxazoles 10 .