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Synthesis of N ‐{[(9 H ‐Fluoren‐9‐yl)methoxy]carbonyl}‐Protected (Fmoc) β‐Amino Acids (= homo‐α‐amino acids) by direct homologation
Author(s) -
EllmererMüller Ernst P.,
Brössner Dagmar,
Maslouh Najib,
Takó Andreas
Publication year - 1998
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19980810107
Subject(s) - chemistry , amino acid , yield (engineering) , stereochemistry , organic chemistry , medicinal chemistry , biochemistry , metallurgy , materials science
The successful application of the Arndt‐Eistert protocol starting from commercially available N ‐{[(9 H ‐fluoren‐9‐yl)methoxy]carbonyl}‐protected (Fmoc) α‐amino acids leading to enantiomerically pure N ‐Fmoc‐protected β‐amino acids in only two steps and with high yield is reported.