Enantioselective 1,4‐Addition of Aliphatic  Grignard  Reagents to Enones Catalyzed by Readily Available Copper(I) thiolates derived from TADDOL. Preliminary communication | Zendy

Seebach Dieter | Zendy; Jaeschke Georg | Zendy; Pichota Arkadius | Zendy; Audergon Laurent | Zendy

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Enantioselective 1,4‐Addition of Aliphatic Grignard Reagents to Enones Catalyzed by Readily Available Copper(I) thiolates derived from TADDOL. Preliminary communication

Author(s) -

Seebach Dieter,

Jaeschke Georg,

Pichota Arkadius,

Audergon Laurent

Publication year - 1997

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19970800819

Subject(s) - chemistry , reagent , enantioselective synthesis , enantiomer , catalysis , copper , organic chemistry , grignard reagent , combinatorial chemistry , medicinal chemistry

Two simple thiols derived from the parent TADDOL, α,α,α′,α′ tetraphenyl‐2,2‐dimethyl‐1,3‐clioxolan‐4,5‐dimethanol, are used to prepare Cu 1 complexes C and D to catalyze (0.05 equiv.) 1,4‐additions of Grignard reagents RMgCl to cyclic enones with enantioselectivities which are comparable to or better than previously reported (enantiomer ratios up to 92:8).

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