New Triterpene Saponins from Herniaria glabra

Three new saponins 1–3 were isolated from Herniaria glabra by means of prep. HPLC and TLC. The structures were established mainly by a combination of 2D‐NMR techniques (COSY, TOCSY, ROESY, HMQC, and HMBC) as O ‐α‐ L ‐rhamnopyranosyl‐(1→4)‐ O ‐β‐ D ‐glucopyranosyl‐(1‐→6)‐ O ‐[β‐ D ‐glucopyranosyl‐(1→2)]‐β‐ D ‐glucopyranosyl medicagen‐28‐ate (herniaria saponin 4; 1 ), O ‐β‐ D ‐glucopyranosyl‐(1→3)‐ O ‐α‐ L ‐rhamnopyranosyl‐(1→2)‐ O ‐[β‐(3 R )‐ D ‐apiofuranosyl‐(1→3)]‐β‐ D ‐4‐ O ‐acetylfucopyranosyl 3‐ O ‐(β‐ D ‐glucuronopyranosyl)‐16α‐hydroxymedicagen‐28‐ate (herniaria saponin 5; 2 ), and O ‐α‐ L ‐rhamnopyranosyl‐(1→4)‐ O ‐β‐ D ‐glucopyranosyl‐(1→6)‐ O ‐[β‐ D ‐6‐ O ‐acetylglucopyra nosyl‐(1→2)]‐β‐ D ‐glucopyranosyl medicagen‐28‐ate (herniaria saponin 6; 3 ).