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Synthesis and Tritium Labelling of 6β‐Amino‐4,5α‐epoxymorphinans and their 14‐hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity
Author(s) -
Ötvös Ferenc,
Tóth Géza,
Lovas Sándor,
Simon Csaba,
Hosztafi Sándor
Publication year - 1996
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19960790114
Subject(s) - chemistry , labelling , tritium , tritium illumination , agonist , affinity label , stereochemistry , specific activity , combinatorial chemistry , organic chemistry , biochemistry , receptor , enzyme , physics , nuclear physics
The synthesis of 6β‐(methylfumaramido) and 6β‐chloroacetamido derivatives 1b and 1c of 6β‐amino‐7,8‐ didehydromorphinan and the corresponding 14‐hydroxy derivatives 1e and 1f are described. The 7,8‐dihydro derivatives of these compounds were synthesized in inactive ( 2b,c,e,f ) as well as in tritiated form ( 3b,c,e,f ).