Enantioselektive Synthese von α‐Phosphinoketonen. Vorläufige Mitteilung | Zendy

Enders Dieter | Zendy; Berg Thorsten | Zendy; Raabe Gerhard | Zendy; Runsink Jan | Zendy

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Enantioselektive Synthese von α‐Phosphinoketonen. Vorläufige Mitteilung

Author(s) -

Enders Dieter,

Berg Thorsten,

Raabe Gerhard,

Runsink Jan

Publication year - 1996

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19960790112

Subject(s) - chemistry , enantioselective synthesis , borane , ozonolysis , enantiomer , stereochemistry , catalysis , organic chemistry

Enantioselective Synthesis of α‐Phosphinoketones The first asymmetric (CP)‐connective synthesis of α‐phosphinoketones in high enantiomeric purity (e.e.91–97%) is described. Key step is the highly diastereoselective phosphinylation of SAMP‐hydrazones ( S )‐ 2 to produce α‐phosphinohydrazones ( S,R )‐ 3 , isolated as the more stable borane adducts. Subsequent ozonolysis afforded the title compounds ( R )‐ 4 , potential ligands for enantioselective homogeneous catalysis.

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