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Stereoselective Partial Synthesis of (+)‐Pisiferic Acid
Author(s) -
Geiwiz Jürgen,
Haslinger Ernst
Publication year - 1995
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19950780404
Subject(s) - chemistry , stereoselectivity , stereochemistry , combinatorial chemistry , organic chemistry , catalysis
(+)‐Pisiferic acid ( 1 ), an antibiotic active against Gram ‐negative and Gram ‐positive bacteria, was synthesized starting from dehydroabietic acid ( 2 ) or abietic acid ( 26 ). The terpene ring system was functionalized and a Barton reaction used to oxidize Me(20). The intermediates of this photochemical reaction were isolated and characterized.