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Synthesis of 4,6,8‐Trisubstituted Methyl Azulene‐2‐carboxylates
Author(s) -
Rippert Andreas Johannes,
Hansen HansJürgen
Publication year - 1995
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19950780121
Subject(s) - chemistry , azulene , sodium carbonate , dimethyl carbonate , boiling , medicinal chemistry , sodium , organic chemistry , catalysis
It is shown that sodium (methoxycarbonyl)cyclopentadienide ( 1 ), which is easily accessible from sodium cyclopentadienide and dimethyl carbonate in THF, reacts with 2,4,6‐trisubstituted pyrylium tetrafluoroborates 2a–d in boiling MeOH to afford the corresponding methyl azulene‐2‐carboxylates 4a–d in good yields. The corresponding 1‐carboxylates 3 were not found ( cf. Schemes 1 and 2 ).