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‘One‐Pot’ Synthesis of Raumacline from Ajmaline
Author(s) -
Endress Susanne,
Stöckigt Joachim
Publication year - 1993
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19930760713
Subject(s) - ajmaline , chemistry , yield (engineering) , biotransformation , alkaloid , transformation (genetics) , stereochemistry , derivative (finance) , organic chemistry , biochemistry , enzyme , medicine , materials science , metallurgy , gene , economics , financial economics
For the alkaloid raumacline ( 2 ), which is a biotransformation product of ajmaline ( 1 ) in Rauwolfia serpentina cell cultures, an efficient ‘one‐pot’ synthesis was developed using a NaBH 4 /riboflavin/light‐mediated transformation of 1 into 2 with a total yield of 86%.
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