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Zur Herstellung von PQQ in kg‐Mengen
Author(s) -
Martin Pierre,
Steiner Eginhard,
Auer Kurt,
Winkler Tammo
Publication year - 1993
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19930760423
Subject(s) - chemistry , yield (engineering) , cofactor , bottleneck , organic chemistry , enzyme , materials science , computer science , embedded system , metallurgy
Preparation of PQQ in the kag Scale The improvement of the PQQ synthesis according to the method of Corey and Tramontano allows the preparation of the triester of this cofactor in the kg scale with an overall yield of 13% (average 78% per step), without a bottleneck in the sequence and with crystalline, analytically pure intermediates. The new purification of free PQQ from conc. H 2 SO 4 is remarkable with respect to the application as well as to the stability of this natural product.