Template‐Assembled Synthetic Proteins (TASP). Cyclic Templates with Incorporated Turn‐Inducing Mimics | Zendy

Earnest Ivan | Zendy; Kalvoda Jaroslav | Zendy; Francotte Eric | Zendy; Rihs Grety | Zendy; Fritz Hans | Zendy; Blommers Marcel J. J. | Zendy; Raschdorf Fritz | Zendy; Sigel Christoph | Zendy; Mutter Manfred | Zendy

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Template‐Assembled Synthetic Proteins (TASP). Cyclic Templates with Incorporated Turn‐Inducing Mimics

Author(s) -

Earnest Ivan,

Kalvoda Jaroslav,

Francotte Eric,

Rihs Grety,

Fritz Hans,

Blommers Marcel J. J.,

Raschdorf Fritz,

Sigel Christoph,

Mutter Manfred

Publication year - 1993

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19930760414

Subject(s) - chemistry , template , dipeptide , cyclic peptide , turn (biochemistry) , peptide , stereochemistry , amino acid , combinatorial chemistry , molecule , biochemistry , nanotechnology , organic chemistry , materials science

The 8‐amino‐5,6,7,8‐tetrahydronaphth‐2‐oic acid ( 1 ), 8‐(aminomethyl)‐5,6,7,8‐tetrahydronaphth‐2‐oic acid ( 2 ), and 8‐(aminomethyl)naphth‐2‐oic acid ( 3 ) were synthesized in their protected forms as turn‐inducing dipeptide mimics. Two of them ( 2 and 3 ) were incorporated into a novel type of cyclic, peptide‐based structures (see 21 and 34 – 36 ) designed as templates for the synthesis of TASP molecules.

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