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Template‐Assembled Synthetic Proteins (TASP). Cyclic Templates with Incorporated Turn‐Inducing Mimics
Author(s) -
Earnest Ivan,
Kalvoda Jaroslav,
Francotte Eric,
Rihs Grety,
Fritz Hans,
Blommers Marcel J. J.,
Raschdorf Fritz,
Sigel Christoph,
Mutter Manfred
Publication year - 1993
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19930760414
Subject(s) - chemistry , template , dipeptide , cyclic peptide , turn (biochemistry) , peptide , stereochemistry , amino acid , combinatorial chemistry , molecule , biochemistry , nanotechnology , organic chemistry , materials science
The 8‐amino‐5,6,7,8‐tetrahydronaphth‐2‐oic acid ( 1 ), 8‐(aminomethyl)‐5,6,7,8‐tetrahydronaphth‐2‐oic acid ( 2 ), and 8‐(aminomethyl)naphth‐2‐oic acid ( 3 ) were synthesized in their protected forms as turn‐inducing dipeptide mimics. Two of them ( 2 and 3 ) were incorporated into a novel type of cyclic, peptide‐based structures (see 21 and 34 – 36 ) designed as templates for the synthesis of TASP molecules.