Synthetische Analoga von niedermolekularen Spinnentoxinen mit Acyl‐polyamin‐Struktur

Synthetic Analogues of Low‐Molecular‐Weight Acyl‐polyamine Spider Toxins Low‐molecular‐weight spider and wasp toxins are selective inhibitors of glutamate receptors of the central nervous system and consist of a polyamine backbone and one or several carboxylic acids and/or amino acids linked by a peptide‐like bond. The syntheses of twelve analogues of spider and wasp toxins are described ( 10a – c , 15a – c , 20a – c , 25a – c ) having the general structure of acyl, arylacyl, or heteroarylacyl → DL ‐alanyl → ω‐aminoacyl → N 1 ‐spermidine, with variation in the acyl and the ω‐aminoacyl part.