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Synthetische Analoga von niedermolekularen Spinnentoxinen mit Acyl‐polyamin‐Struktur
Author(s) -
Fiedler Wolfgang J.,
Guggisberg Armin,
Hesse Manfred
Publication year - 1993
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19930760304
Subject(s) - chemistry , spider toxin , spermidine , polyamine , stereochemistry , spider , peptide , receptor , glutamate receptor , biochemistry , enzyme , zoology , biology
Synthetic Analogues of Low‐Molecular‐Weight Acyl‐polyamine Spider Toxins Low‐molecular‐weight spider and wasp toxins are selective inhibitors of glutamate receptors of the central nervous system and consist of a polyamine backbone and one or several carboxylic acids and/or amino acids linked by a peptide‐like bond. The syntheses of twelve analogues of spider and wasp toxins are described ( 10a – c , 15a – c , 20a – c , 25a – c ) having the general structure of acyl, arylacyl, or heteroarylacyl → DL ‐alanyl → ω‐aminoacyl → N 1 ‐spermidine, with variation in the acyl and the ω‐aminoacyl part.