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Ruthenium‐Catalyzed Enantioselective Hydrogenation of 1,3‐ O ‐Disubstituted 1,3‐Dihydroxypropan‐2‐ones
Author(s) -
Cesarotti Edoardo,
Antognazza Patrizia,
Mauri Angela,
Pallavicini Marco,
Villa Luigi
Publication year - 1992
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19920750811
Subject(s) - chemistry , enantioselective synthesis , ruthenium , catalysis , binap , homogeneous , asymmetric hydrogenation , optically active , noyori asymmetric hydrogenation , medicinal chemistry , organic chemistry , combinatorial chemistry , combinatorics , mathematics
Optically active 1,3‐ O ‐disubstituted glycerols were obtained by enantioselective homogeneous hydrogenation of the corresponding 1,3‐ O ‐disubstituted 1,3‐dihydroxypropan‐2‐ones with different Ru II ‐binap complexes. The highest enantioselectivities were obtained with dimeric chloro‐ruthenium complexes on the substrates bearing bulky trityloxy groups.