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Synthesis of New Glycerolipids Linked to Hydroxamate Derivatives Designed for Two‐Dimensional Crystallization of Aminopeptidase M
Author(s) -
Altenburger JeanMichel,
Lebeau Luc,
Mioskowski Charles,
Schirlin Daniel
Publication year - 1992
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19920750808
Subject(s) - chemistry , crystallization , aminopeptidase , stereochemistry , biochemistry , organic chemistry , amino acid , leucine
The synthesis of glycerolipids linked to hydroxamate derivatives designed for two‐dimensional crystallization of aminopeptidase M is reported. The lipid moieties are readily obtained using a convergent pathway. Their structure allows the introduction of a wide variety of ligands of biological interest.