High‐Yield Formation of Arbutin from Hydroquinone by Cell‐Suspension Cultures of  Rauwolfia serpentina | Zendy

Lutterbach Ralf | Zendy; Stöckigt Joachim | Zendy

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High‐Yield Formation of Arbutin from Hydroquinone by Cell‐Suspension Cultures of Rauwolfia serpentina

Author(s) -

Lutterbach Ralf,

Stöckigt Joachim

Publication year - 1992

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19920750625

Subject(s) - arbutin , hydroquinone , chemistry , yield (engineering) , glycoside , suspension culture , botany , cell culture , organic chemistry , chromatography , biology , metallurgy , genetics , materials science

High‐density cell‐suspension cultures of Rauwolfia serpentina cultivated in a nutrition medium optimized for the production of the glucoalkaloid raucaffricine synthesize hydroquinone glycosides from continuously added hydroquinone with a total yield of 23.87 g/1 (18 g/1 of arbutin and 5.87 g/1 of a hydroquinone diglycoside) in 7 days. This arbutin production is by far the highest formation of a natural product by plant‐cell‐culture systems reported to date.

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