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High‐Yield Formation of Arbutin from Hydroquinone by Cell‐Suspension Cultures of Rauwolfia serpentina
Author(s) -
Lutterbach Ralf,
Stöckigt Joachim
Publication year - 1992
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19920750625
Subject(s) - arbutin , hydroquinone , chemistry , yield (engineering) , glycoside , suspension culture , botany , cell culture , organic chemistry , chromatography , biology , metallurgy , genetics , materials science
High‐density cell‐suspension cultures of Rauwolfia serpentina cultivated in a nutrition medium optimized for the production of the glucoalkaloid raucaffricine synthesize hydroquinone glycosides from continuously added hydroquinone with a total yield of 23.87 g/1 (18 g/1 of arbutin and 5.87 g/1 of a hydroquinone diglycoside) in 7 days. This arbutin production is by far the highest formation of a natural product by plant‐cell‐culture systems reported to date.