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Reaction of Diphenyl Phosphorochloridate with Amide Enolates: A new and convenient synthesis of 2‐monosubstituted 3‐( n ‐methyl‐ n ‐phenylamino)‐2 H ‐azirines
Author(s) -
Villalgordo José M.,
Heimgartner Heinz
Publication year - 1992
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19920750612
Subject(s) - chemistry , amide , reactivity (psychology) , stereochemistry , medicinal chemistry , organic chemistry , medicine , alternative medicine , pathology
Reaction of diphenyl phosphorochloridate with amide enolates and subsequent treatment with NaN 3 leads to 2‐monosubstituted 3‐amino‐2 H ‐azirines 5 in moderate yields. The reactivity of these azirines is briefly explored.