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A Complex Pyrrolo‐oxazinone and Its Iodo Derivative Isolated from a Tunicate
Author(s) -
Yoshida Wesley Y.,
Lee Kit K.,
Carroll Anthony R.,
Scheuer Paul J.
Publication year - 1992
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19920750525
Subject(s) - tunicate , chemistry , cytotoxicity , stereochemistry , derivative (finance) , cytotoxic t cell , in vitro , biochemistry , ecology , economics , financial economics , biology
Two cytotoxic triphenylpyrrolo‐oxazinones were isolated from a tunicate and their structures elucidated by spectral methods. Lukianol A ( = 3,7,8‐tris(4‐hydroxyphenyl)pyrrolo[2,1‐c][1,4]oxazin‐1 (1 H)‐ one ; 1 ) had MIC of 1 μg/ml in KB cytotoxicity tests; MIC value for 2 was 100 μg/ml.