Tritium Labelling of Cyprodime ( = (—)‐17‐(Cyclopropylmethyl)‐4,14‐dimethoxymorphinan‐6‐one), a μ Receptor‐Selective Opioid Antagonist | Zendy

Ötvös Ferenc | Zendy; Tóth Géza | Zendy; Schmidhammer Helmut | Zendy

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Tritium Labelling of Cyprodime ( = (—)‐17‐(Cyclopropylmethyl)‐4,14‐dimethoxymorphinan‐6‐one), a μ Receptor‐Selective Opioid Antagonist

Author(s) -

Ötvös Ferenc,

Tóth Géza,

Schmidhammer Helmut

Publication year - 1992

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19920750524

Subject(s) - chemistry , tritium , halogenation , labelling , tritium illumination , catalysis , antagonist , opioid receptor , combinatorial chemistry , radiochemistry , medicinal chemistry , stereochemistry , receptor , nuclear chemistry , organic chemistry , biochemistry , physics , nuclear physics

The preparation of [1‐ 3 H]cyprodime ( 2 ), which has a specific activity of 31.6 Ci/mmol was carried out by catalytic tritiodehalogenation of 1‐bromocyprodime ( 3 ). Bromination of cyprodime was performed by using chloroperoxidase, KBr, and H 2 O 2 .

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