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Tritium Labelling of Cyprodime ( = (—)‐17‐(Cyclopropylmethyl)‐4,14‐dimethoxymorphinan‐6‐one), a μ Receptor‐Selective Opioid Antagonist
Author(s) -
Ötvös Ferenc,
Tóth Géza,
Schmidhammer Helmut
Publication year - 1992
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19920750524
Subject(s) - chemistry , tritium , halogenation , labelling , tritium illumination , catalysis , antagonist , opioid receptor , combinatorial chemistry , radiochemistry , medicinal chemistry , stereochemistry , receptor , nuclear chemistry , organic chemistry , biochemistry , physics , nuclear physics
The preparation of [1‐ 3 H]cyprodime ( 2 ), which has a specific activity of 31.6 Ci/mmol was carried out by catalytic tritiodehalogenation of 1‐bromocyprodime ( 3 ). Bromination of cyprodime was performed by using chloroperoxidase, KBr, and H 2 O 2 .