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Pterin Chemistry. Part 92. . Loading experiments with 6α,β‐tetrahydro‐ L ‐[3′‐ 2 H 1 ] biopterin
Author(s) -
Adler Carmen,
Curtius HansChristoph,
Wetzel Erich,
Viscontini Max,
Giudici Tullio A.,
Blaskovics Milan,
Rolland Marie O.,
Guibaud Pierre
Publication year - 1992
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19920750423
Subject(s) - biopterin , pterin , chemistry , intramolecular force , urine , stereochemistry , isotopomers , biochemistry , organic chemistry , cofactor , molecule , enzyme , tetrahydrobiopterin
6α,β‐Tetrahydro‐ L ‐[3′‐ 2 H 1 ]biopterin ([3′‐ 2 H 1 ]‐ 1 ) was administered orally to two primapterinuric patients in order to investigate the biosynthetic pathway of 7‐substituted pterins in humans. L ‐Primapterin ( 2 ) and L ‐biopterin were isolated from urine after loading and measured by GC/MS. L ‐Biopterin and L ‐primapterin were labelled with 2 H to an equal extent. From this result, one can conclude that L ‐primapterin is formed from tetrahydro‐ L ‐biopterin, very probably via an intramolecular rearrangement.