Stereoselective Hydrolysis of Substituted Cyclopropanedicarboxylates with Pig Liver Esterase | Zendy

Walser Paula | Zendy; Renold Peter | Zendy; N'Goka Victor | Zendy; Hosseinzadeh Fatemeh | Zendy; Tamm Christoph | Zendy

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Stereoselective Hydrolysis of Substituted Cyclopropanedicarboxylates with Pig Liver Esterase

Author(s) -

Walser Paula,

Renold Peter,

N'Goka Victor,

Hosseinzadeh Fatemeh,

Tamm Christoph

Publication year - 1991

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19910740832

Subject(s) - chemistry , esterase , pig liver , cyclopropane , stereoselectivity , hydrolysis , stereochemistry , organic chemistry , enzyme , catalysis , ring (chemistry)

The hydrolysis of the meso ‐cyclopropane‐1,2‐dicarboxylates 1a ‐ 3a , 4 , 5a , 6a , and 9 , containing various substituents at C(3), and of the rac ‐3‐phenylcyclopropane‐1,2‐dicarboxylates 7a , 8a , and 10 with pig liver esterase (PLE) is described. The stereoselectivtty and absolute configurations of the products were determined. An interpretation of results was attempted on the basis of a recent active‐site model for PLE.

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