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The Reaction of 1,2:3,4‐Diepoxy‐2,3‐dimethylbutane with Nucleophiles
Author(s) -
Farkas Frédéric,
Wellauer Thomas,
Esser Thomas,
Séquin Urs
Publication year - 1991
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19910740715
Subject(s) - chemistry , nucleophile , medicinal chemistry , computational chemistry , organic chemistry , catalysis
To find out whether the 1,4‐addition to 1,2:3,4‐diepoxides, which so far has been observed only once, is of a more general character, we investigated the reaction of a variety of O‐, C‐, N‐, and S‐nucleophiles with the model compound 1,2:3,4‐diepoxy‐2,3‐dimethylbutane ( Scheme 4 ). In several cases, 1,4‐addition products could, indeed, be observed besides the expected 1,2‐adducts ( Table ).
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