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Ruthenium(II) Complex of the Alkaloid 2‐Bromoleptoclinidinone. Preparation and Interaction with Double‐Stranded DNA
Author(s) -
Goullc Véronique,
Lehn JeanMarie,
Schoentjes Bruno,
Schmitz Francis J.
Publication year - 1991
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19910740711
Subject(s) - chemistry , ruthenium , intercalation (chemistry) , dna , alkaloid , hexafluorophosphate , stereochemistry , octahedron , chelation , denticity , dna supercoil , cleavage (geology) , pbr322 , crystallography , plasmid , crystal structure , organic chemistry , catalysis , biochemistry , ionic liquid , dna replication , geotechnical engineering , fracture (geology) , engineering
The fused pentacyclic alkaloid 2‐bromoleptoclinidinone ( 1 ) isolated from an ascidian possesses a bidentate chelating site. Complexation of 1 with [ cis ‐RuCl 2 {(D 8 )bpy} 2 ] · 2H 2 O forms an octahedral complex which was isolated both as hexafluorophosphate 2 and chloride 3 salts. Intercalation of 3 in calf‐thymus DNA was shown to occur as well as photoactivated cleavage of double‐strand supercoiled DNA pBR322 under visible‐light irradiation.