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Alternative Strategies for the Fmoc Solid‐Phase Synthesis of O 4 ‐Phospho‐L‐tyrosine‐Containing Peptides
Author(s) -
Kitas Eric A.,
Knorr Reinhard,
Trzeciak Arnold,
Bannwarth Willi
Publication year - 1991
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19910740621
Subject(s) - chemistry , tyrosine , moiety , peptide , solid phase synthesis , tyrosine phosphorylation , side chain , phosphorylation , phosphate , peptide synthesis , stereochemistry , combinatorial chemistry , biochemistry , organic chemistry , polymer
A number of biologically relevant O 4 ‐phospho‐L‐tyrosine‐containing peptides have been synthesized by either the global phosphorylation of the side‐chain‐unprotected L‐tyrosine moiety in presynthesized resin‐bound peptides or alternatively by the incorporation of suitably protected O 4 ‐phospho‐L‐tyrosine building blocks in the continuous‐flow method of Fmoc solid‐phase peptide synthesis. Different phosphate‐protecting groups have been applied.