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Site‐Selectivity in the Fe + ‐Mediated CH/CC Bond Activation of Aldimines Short Communication
Author(s) -
Prüsse Tilmann,
Schwarz Helmut
Publication year - 1991
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19910740604
Subject(s) - aldimine , chemistry , alkyl , dehydrogenation , selectivity , alkene , medicinal chemistry , stereochemistry , organic chemistry , catalysis
It is demonstrated for the first time that the site‐selectivity for the Fe + ‐mediated CH bond activation of aldimines R 1 NCHR 2 (R 1 , R 2 = alkyl) involves the alkyl chain R 1 by a factor ≥ 12 in comparison to the alkenyl part R 2 . This finding explains previous observations that dehydrogenation of intermediates formed by alkene loss from either R 1 or R 2 of R 1 NCHR 2 /Fe + preferentially involves the alkyl part.