Premium
[5‐Leucin]enkephalin‐Related Glycoconjugates: Structurally Novel Agents Effective against HIV‐1
Author(s) -
Horvat Štefica,
Varga Lidija,
Horvat Jaroslav,
Pfützner Andreas,
Suhartono Haryadi,
RübsamenWaigmann Helga
Publication year - 1991
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19910740505
Subject(s) - glycoconjugate , chemistry , enkephalin , ether , human immunodeficiency virus (hiv) , biochemistry , opioid , virology , organic chemistry , receptor , biology
Abstract A series of [Leu 5 ]enkephalin‐related glycoconjugates with an ester‐, ether‐, or amide‐type linkage were synthesized and evaluated for antiviral activity against HIV‐1 in a cell‐culture system using peripheral blood lymphocytes. All tested glycoconjugates exhibited a certain antiviral activity which was significantly higher than the activity of the parent peptide compound itself. These results indicate that synthetic glycoconjugates of opioid peptides are good candidates for the development of anti‐HIV agents.