Nucleotides. Part XXXV . Synthesis of 3′‐deoxyadenylyl‐(2′–5′)‐3′‐deoxyadenyIyl‐(2′–ω)‐9‐(ω‐hydroxyalkyl)adenines | Zendy

Mikhailov Sergey N. | Zendy; Charubala Ramamurthy | Zendy; Pfleiderer Wolfgang | Zendy

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Nucleotides. Part XXXV . Synthesis of 3′‐deoxyadenylyl‐(2′–5′)‐3′‐deoxyadenyIyl‐(2′–ω)‐9‐(ω‐hydroxyalkyl)adenines

Author(s) -

Mikhailov Sergey N.,

Charubala Ramamurthy,

Pfleiderer Wolfgang

Publication year - 1991

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19910740419

Subject(s) - chemistry , nucleotide , high performance liquid chromatography , stereochemistry , oligonucleotide , combinatorial chemistry , organic chemistry , biochemistry , dna , gene

Via the phosphotriester approach, new structural analogs of (2′–5′)oligoadenyiates, namely 3′‐deoxyadenylyl‐(2′–5′)‐3′‐dcoxyadenylyl‐(2′–ω)‐9‐(ω‐hydroxyalkyl)adenines 18 – 21 , have been synthesized (see Scheme ) which should preserve biological activity and show higher stability towards phosphodiesterases. The newly synthesized oligonucleotides 18 – 21 have been characterized by 1 H‐NMR spectra, TLC, and HPLC analysis.

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