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Nucleotides. Part XXXV . Synthesis of 3′‐deoxyadenylyl‐(2′–5′)‐3′‐deoxyadenyIyl‐(2′–ω)‐9‐(ω‐hydroxyalkyl)adenines
Author(s) -
Mikhailov Sergey N.,
Charubala Ramamurthy,
Pfleiderer Wolfgang
Publication year - 1991
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19910740419
Subject(s) - chemistry , nucleotide , high performance liquid chromatography , stereochemistry , oligonucleotide , combinatorial chemistry , organic chemistry , biochemistry , dna , gene
Via the phosphotriester approach, new structural analogs of (2′–5′)oligoadenyiates, namely 3′‐deoxyadenylyl‐(2′–5′)‐3′‐dcoxyadenylyl‐(2′–ω)‐9‐(ω‐hydroxyalkyl)adenines 18 – 21 , have been synthesized (see Scheme ) which should preserve biological activity and show higher stability towards phosphodiesterases. The newly synthesized oligonucleotides 18 – 21 have been characterized by 1 H‐NMR spectra, TLC, and HPLC analysis.