4 H ‐Chromenone Glycosides from Eranthis hyemalis (L.) S ALISBURY

Investigation of the tubers of Eranthis hyemalis ( Ranunculaceae ) afforded six chromenone glycosides. Their structures have been elucidated mainly by spectroscopic (FAB‐MS, 2D‐NMR techniques) and chemical methods (acidic and enzymatic hydrolysis) as 9‐{[(β‐ D ‐glucopyranosyl)oxy]methyl}‐8,11‐dihydro‐5‐hydroxy‐2‐methyl‐4 H ‐pyrano[2,3‐ g ][1]benzoxepin‐4‐one ( 1 ), 9‐{[(β‐ D ‐gentiobiosyl)oxy]methyl}‐8,11‐dihydro‐5‐hydroxy‐2‐methyl‐4 H ‐pyrano[2,3‐ g ][1]benzoxepin‐4‐one( 2 ), 9‐{[(β‐ D ‐glucopyranosvl)oxy]melhyl}‐8,11‐dihydro‐5‐hydroxy‐2‐(hydroxy‐methyl)‐4 H ‐pyrano[2,3‐ g ][1]benzoxepin‐4‐one( 3 ), 8‐{(2 E )‐4‐[(β‐ D ‐glucopyranosyl)oxy]‐3‐methylbut‐2‐enyl}‐5,7‐dihydroxy‐2‐methyl‐4 H ‐1‐benzopyran‐4‐one ( 4 ), 8‐{(2 E )‐4‐[(β‐ D ‐glucopyranosyi)oxy]‐3‐methylbut‐2‐enyl}‐5,7‐dihydroxy‐2‐(hydroxymethyl)‐4 H ‐1‐benzopyran‐4‐one ( 5 ), and 7‐{[(β‐ D ‐glucopyranosy1)oxy]methyl}‐2,3‐dihydro‐2‐(l‐hydroxy‐1‐methylethyl)‐4‐methoxy‐5 H ‐furo[3,2‐ g ][1]benzopyran‐5‐one ( 6 ). Compound 2 exhibited negative inotropic activity.