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Biosynthesis of the Spermine Alkaloid Aphelandrine
Author(s) -
Papazoglou Georgios,
Sierra Jorge,
Homberger Katharina,
Guggisberg Armin,
Woggon WolfDietrich,
Hesse Manfred
Publication year - 1991
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19910740313
Subject(s) - spermidine , spermine , putrescine , chemistry , biosynthesis , alkaloid , stereochemistry , hydrolysis , biochemistry , polyamine , enzyme
Aphelandrine ( 1 ) is shown to be biosynthesized in the root cells of Aphelandra tetragona (V AHL ) N EES from labelled putrescine ( 4 ), spermidine ( 5 ), and cinnamic acid ( 3 ). Whether spermine ( 6 ) and the ( p ‐hydroxycinnamoyl)spermidine 8 are precursors of 1 is uncertain, since the latter is hydrolysed to a large extent before incorporation, and the former is metabolized to 4 and 5 . Methionine ( 7 ) is the source of the 3‐aminopropyl unit of 5 and 6 .