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Transformations in the Isoxazole Series: Synthesis of Substituted 2‐Aminothiazoles
Author(s) -
Pascual Alfons
Publication year - 1991
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19910740309
Subject(s) - chemistry , isoxazole , scope (computer science) , yield (engineering) , combinatorial chemistry , transformation (genetics) , series (stratigraphy) , organic chemistry , biochemistry , programming language , paleontology , materials science , biology , metallurgy , gene , computer science
Substitued N ‐(isoxazol‐4‐yl)thioureas 1 undergo a transformation in the presence of hexacarbonylmolybdenum and acid to yield functionalized thiazoles 3 in a one‐pot reaction. In a few cases, 1,4,5‐trisubstituted dihydroimidazolethiones 4 are also isolated as side products. Mechanistic considerations are outlined and scope and limitations of this new methodology discussed.