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On the Regioselectivity Control in the Palladium‐Catalyzed Hydro‐alkoxycarbonylation of α,β‐Unsaturated Esters
Author(s) -
Consiglio Giambattista,
Nefkens Sylvia C. A.,
Pisano Carmelina,
Wenzinger Fritz
Publication year - 1991
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19910740210
Subject(s) - chemistry , regioselectivity , carbonylation , diphenylphosphine , ligand (biochemistry) , phosphine , palladium , medicinal chemistry , catalysis , acrylate , methylene , organic chemistry , carbon monoxide , copolymer , biochemistry , polymer , receptor
The regioselectivity of the hydro‐alkoxycarbonylation of methyl acrylate, methacrylate, and crotonate catalyzed by [PdCl 2 L 2 ] complexes (L = phosphine ligands) can be largely controlled by variation of the ligands. PPh 3 , promotes preferential carbonylation at the α‐position, whereas with [(2,2‐dimethyl‐1,3‐dioxolane‐4,5‐diyl)bis‐(methylene)]bis[diphenylphosphine] as ligand, the β‐position is overwhelmingly carbonylated.