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Synthesis of 24‐Methylidene[24‐ 14 C]‐ and 24‐Methylidene[7‐ 3 H]cholesterol
Author(s) -
Monteagudo Edith S.,
Burton Gerardo,
Gros Eduardo G.
Publication year - 1990
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19900730805
Subject(s) - chemistry , cholesterol , stereochemistry , organic chemistry , biochemistry
The syntheses of 24‐methylidene[24‐ 14 C]cholesterol ( 7a ) and of 24‐methylidene[7‐ 3 H]cholesterol ( 7b ) from commercially available (20 S )‐3‐oxopregn‐4‐ene‐20‐carbaldehyde ( 1 ) are described. The method also provides simple preparations of 3β‐acetoxy[24‐ 14 C]chol‐5‐en‐24‐oic acid ( 4 ) and 24‐oxocholest‐5‐en‐3β‐yl acetate ( 6b ).