Reduction of Indolin‐2‐ones and Desulfurization of Indoline‐2‐thiones to Indoline and Indole Derivatives | Zendy

Nishio Takehiko | Zendy; Okuda Norikazu | Zendy; Kashima Choji | Zendy

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Reduction of Indolin‐2‐ones and Desulfurization of Indoline‐2‐thiones to Indoline and Indole Derivatives

Author(s) -

Nishio Takehiko,

Okuda Norikazu,

Kashima Choji

Publication year - 1990

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19900730616

Subject(s) - indoline , chemistry , indole test , yield (engineering) , lithium aluminium hydride , aluminum hydride , medicinal chemistry , flue gas desulfurization , organic chemistry , raney nickel , hydride , catalysis , hydrogen , materials science , metallurgy , methoxide

Reduction of indolin‐2‐ones with lithium aluminium hydride (LAH) or diisobutylaluminum hydride (DIBAL) and desulfurization of indoline‐2‐thiones with Raney ‐Ni were investigated. Treatment of indoline‐2‐ones 1 with LAH or DIBAL yield indoles 4 and/or indolines 3 in moderate‐to high yield depending on the substituents at N and C(3) of 1 . Indoline‐2‐thiones 2 were desulfurized with Raney ‐Ni to give indoles 4 and/or indolines 3 .

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