2‐Aza‐l, 3‐dienes. Partie 6. Observation d′un effet ‘ tert ‐amino’ dans le traitement acide de (pyrrolidin‐l‐yl)‐azadienes | Zendy

Legroux Didier | Zendy; Brotn Jacques | Zendy; Fleury Jean Pierre | Zendy

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2‐Aza‐l, 3‐dienes. Partie 6. Observation d′un effet ‘ tert ‐amino’ dans le traitement acide de (pyrrolidin‐l‐yl)‐azadienes

Author(s) -

Legroux Didier,

Brotn Jacques,

Fleury Jean Pierre

Publication year - 1990

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19900730509

Subject(s) - chemistry , pyrazine , stereochemistry , medicinal chemistry , morpholino , biochemistry , zebrafish , gene

‘ tert ‐Amino Effect’ on Acidic Treatment of (Pyrrolidin‐l‐yl)azadienes The behaviour of 4‐morpholino‐ and 4‐(pyrrolidin‐l‐yl)‐2‐aza‐1. 3‐diene‐l, l‐dicarbonitriles 3 , and 4 and 10 , respectively, in acidic medium is described. The former gives with HBr/AcOH 3‐bromopyrazine‐2‐carbonitrile 6. On the other hand, pyrrolidin‐1‐yl derivatives 4 and 10 furnish, by a [1, 5]‐H shift, pyrrolo[l, 2]pyrazine structures 5 and 11 , respectively.

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