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Der Zugang zum Antitumor‐Antibiotikum CC‐1065 mittels Hetero‐Cope‐Umlagerung von Vinyl‐N‐phenylhydroxamaten
Author(s) -
Martin Pierre
Publication year - 1989
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19890720717
Subject(s) - chemistry , stereochemistry , antibiotics , phosphodiesterase , enzyme , biochemistry
The Access to the Three Subunits of the Antitumor Antibiotic CC ‐ 1065 by Hetero‐ Cope Rearrangement of Vinyl N ‐Phenylhydroxamates . The use of the hetero‐ Cope rearrangement of vinyl N phenylhydroxamates to indoles for the preparation of the 1,2‐dihydro‐3 H , 6 H ‐benzo[1,2‐b:4,3‐b′]dipyrrole skeleton, the structural subunits characteristic of the antitu‐mor antibiotic CC ‐ 1065 as well as the phosphodiesterase inhibitors PDE ‐ I and PDE ‐ II is described.