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Ring‐opened analogues of Ambrox ® : Synthesis and Structure‐Odour relationships
Author(s) -
Winter Beat
Publication year - 1989
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19890720614
Subject(s) - chemistry , steric effects , bicyclic molecule , ether , ring (chemistry) , tricyclic , stereochemistry , organic chemistry
Eight bicyclic ether derivatives 11 – 18 , related to the tricyclic odorant Ambrox ® ( 1 ) and its analogues 2 – 6 by formal heteroring‐opening, have been prepared; their odoriferous activity/in activity is correlated with the steric accessibility of the ether O‐atom, calculated by computer‐aided molecular modeling.