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Synthesis of Polyaza Macrocyclic Ligands Incorporating Pyridine Units
Author(s) -
Hosseini Mir Wais,
Comarmond Jacques,
Lehn JeanMarie
Publication year - 1989
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19890720525
Subject(s) - chemistry , protonation , pyridine , hydrolysis , cyclophane , stereochemistry , nucleotide , metal , combinatorial chemistry , medicinal chemistry , organic chemistry , molecule , biochemistry , ion , gene
The synthesis of nine macrocyclic polyamines 2‐10 containing pyridine units is described. These compounds are 22‐ ( 9 ), 24‐ ( 2‐4,6,8,10 ), or 26‐ ( 5 , 7 ) membered hexaaza ( 2,3,9,10 ) or octaaza ( 4–7 ) macrocycles in which one to four pyridine units are incorporated. Compounds 3,4,9 , and 10 are homoditopic ligands, whereas 2 and 5 are heteroditopic and 6−8 multitopic receptors. Compounds 2‐10 are potential ligands for metal cations as well as, in their protonated forms, for anions. Protonated macrocycles 2−10 are also potential catalysts for the hydrolysis of nucleotides and polyphosphates.